https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48706 30 minutes] IRR=1.11 [1.04, 1.19]) and fewer specialist attendances (IRR=0.91 [0.85, 0.97]) and were more likely to have an emergency GP attendance (OR=2.29 [2.05, 2.57]). There were no significant differences in the odds of having either a HA or CDM or using allied health services for women with and without dementia indicators. Conclusions: The overall use of services designed to improve the prevention and coordination of the care of older people with chronic conditions was low. Women with dementia were no more likely to access these services. Implications for public health: There is underuse of some primary and allied healthcare services designed for people with complex chronic conditions. These could be better used by women with dementia to improve the management of complex comorbidities (e.g. CDMs), to prevent the onset of disability (e.g. physiotherapy), and enhance needs assessment and service access (e.g. HAs).]]> Wed 29 Mar 2023 15:32:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43709 Wed 28 Sep 2022 10:15:57 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52466 Wed 28 Feb 2024 15:41:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53917 Wed 28 Feb 2024 15:39:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52050 1.1 million by 2058.2 The annual care costs are estimated to increase from $9.1 billion in 2017 to A$24.1 billion by 2056.3 Currently, there is a lack of a single valid and reliable data source for dementia identification. Welberry et al. recently demonstrated the feasibility of linking large population-based cohorts to administrative datasets to identify dementia cases at different stages of their trajectory.4 The Addressing Dementia Through Analysis of Population Traits and Risk Factors (ADAPTOR) project links data from a large Australian cohort study (followed up for 15 years) to various administrative health datasets. While the project links the same cohort study (the Sax Institute’s 45 And Up Study) and administrative datasets for dementia identification, it expands on Welberry et al.’s study by extending the data cut-off period from June 2014 to June 2018; including additional datasets and participants aged between 45–54 years; and stratifying data by sex and age group. The ADAPTOR project estimates dementia incidence, investigates the association between risk factors and incidence, and models the impact of modifiable risk factor reduction (e.g. increased physical activity, reduced alcohol consumption) on population-level dementia incidence. This paper presents preliminary findings from the project on sex and age-specific incidence of dementia and presents the most common data sources for dementia identification.]]> Wed 27 Sep 2023 15:29:45 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45212 Wed 26 Oct 2022 15:56:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45253 n = 217) who visited the specialty outpatient clinic of four hospital departments. The survey was conducted using an iPad with answers sent automatically to a secure server. The survey included items about the participants' most feared diseases and the reasons behind those fears, estimates of dementia prevalence in Japan, and preferences regarding a diagnosis of dementia and the reasons for their preference. Results: The most feared disease was cancer (43.8 %), followed by dementia (18 %). Those selecting dementia most commonly reported practical, emotional and social impacts as the reasons why they most feared this condition. Almost all participants preferred to know the diagnosis of dementia as soon as possible for themselves, with significantly fewer preferring their spouse to know as soon as possible if they had dementia (95.9 % for self vs. 67.5 % for partner/spouse, p < 0.001). On average, participants estimated that 18.1 % of Japanese people are diagnosed with dementia by age 65, while they thought that 43.7 % of Japanese people are diagnosed with dementia by age 85. Conclusions: The findings highlight a need for community education about the significant impacts of dementia on the lives of individuals and their caregivers. People were more reluctant for their spouse to receive a diagnosis as soon as possible if they had dementia. Physicians should sensitively disclose diagnosis and ensure they involve both the patient and their relatives in discussions about diagnosis disclosure.]]> Wed 26 Oct 2022 15:35:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50454 Wed 26 Jul 2023 13:21:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48158 Wed 24 Apr 2024 11:38:58 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51144 Wed 23 Aug 2023 12:29:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51821 Wed 20 Sep 2023 09:59:54 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40887 Wed 20 Jul 2022 10:39:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47145 Wed 14 Dec 2022 15:27:34 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39133 Wed 13 Mar 2024 14:14:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48072 Wed 13 Mar 2024 14:04:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44101 Wed 13 Mar 2024 09:41:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55656 Wed 12 Jun 2024 10:07:37 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50101 Wed 12 Jul 2023 14:18:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53712 Wed 10 Jan 2024 11:10:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53699 Wed 10 Jan 2024 10:48:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41110 Wed 06 Mar 2024 15:23:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46075 Wed 06 Mar 2024 15:05:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48466 Wed 06 Mar 2024 14:28:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54633 Wed 06 Mar 2024 11:00:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45655 Wed 02 Nov 2022 15:45:00 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36552 Tue 30 Jun 2020 12:45:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53477 Tue 28 Nov 2023 16:01:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50963 Tue 22 Aug 2023 11:46:07 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55370 Tue 21 May 2024 13:35:53 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37371 Tue 20 Oct 2020 14:31:08 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54367 Tue 20 Feb 2024 19:56:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35520 Tue 20 Aug 2019 16:30:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40883 Tue 19 Jul 2022 14:52:21 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46292 n = 51). Participants completed an online survey that consisted of fixed-responses and free-text components to assess their knowledge, attitudes and current practices relating to dementia risk factors and risk reduction techniques. The results showed that Australian primary healthcare providers have good knowledge about the modifiable risk factors for dementia; however, face several barriers to working with patients to reduce dementia risk. Commonly reported barriers included low patient motivation and healthcare system level limitations. The most commonly reported recommendations to helping primary healthcare providers to work with patients to reduce dementia risk included increasing resources and improving dementia awareness and messaging. While the results need to be interpreted in the context of the limitations of this study, we conclude that collaborative efforts between researchers, clinicians, policy makers and the media are needed to support the uptake of risk reduction activities in primary care settings.]]> Tue 15 Nov 2022 08:50:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54247 Tue 13 Feb 2024 13:19:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47035 Tue 13 Dec 2022 14:15:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53636 Tue 12 Dec 2023 16:00:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44314 Tue 11 Oct 2022 16:19:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45999 Tue 08 Nov 2022 16:18:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45964 Tue 08 Nov 2022 13:30:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54123 Tue 06 Feb 2024 11:21:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38087 Tue 03 Aug 2021 18:28:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51326 Thu 31 Aug 2023 14:34:53 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55008 Thu 28 Mar 2024 15:43:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45319 Thu 27 Oct 2022 13:45:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45236 Thu 27 Oct 2022 13:45:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51680 Thu 14 Sep 2023 15:52:08 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54812 Thu 14 Mar 2024 14:31:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38637 Thu 14 Mar 2024 08:30:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39908 Thu 14 Jul 2022 12:27:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49316 Thu 11 May 2023 14:53:03 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42951 KCNJ2 gene involved in the transduction of sour taste have been linked to variations in sour taste and non-gustatory functions. However, relationships between sour taste genetics, mild cognitive impairment, and diet quality are yet to be elucidated. This study investigated the associations between the presence of the KCNJ2-rs236514 variant (A) allele, diet quality indices, and mild cognitive impairment evaluated by the Mini-Mental State Examination (MMSE), in a secondary cross-sectional analysis of data from the Retirement Health & Lifestyle Study. Data from 524 elderly Australians (≥65y) were analyzed, using standard least squares regression and nominal logistic regression modeling, with demographic adjustments applied. Results showed that the presence of the KCNJ2-A allele is associated with increased proportions of participants scoring in the range indicative of mild or more severe cognitive impairment (MMSE score of ≤26) in the total cohort, and males. These associations remained statistically significant after adjusting for age, sex, and diet quality indices. The absence of association between the KCNJ2-A allele and cognitive impairment in women may be related to their higher diet quality scores in all indices. The potential link between sour taste genotype and cognitive impairment scores may be due to both oral and extra-oral functions of sour taste receptors. Further studies are required on the role and relationship of neurotransmitters, sour taste genotypes and sour taste receptors in the brain, and dietary implications, to identify potential risk groups or avenues for therapeutic or prophylactic interventions.]]> Thu 08 Sep 2022 14:04:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55552 Thu 06 Jun 2024 10:13:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52237 Thu 05 Oct 2023 11:40:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55046 Thu 04 Apr 2024 13:58:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55029 Thu 04 Apr 2024 09:04:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48130 Thu 02 Mar 2023 15:41:31 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42706 Thu 01 Sep 2022 09:55:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46802 Thu 01 Dec 2022 09:25:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37185 Mon 31 Aug 2020 10:58:00 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36661 Mon 26 Aug 2024 08:39:38 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54964 Mon 25 Mar 2024 12:03:55 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44740 Mon 24 Oct 2022 08:35:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44734 Mon 24 Oct 2022 08:28:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49545 Mon 22 May 2023 08:45:20 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49537 Mon 22 May 2023 08:38:22 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53955 Mon 22 Jan 2024 17:03:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46409 Mon 21 Nov 2022 11:52:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40743 Mon 18 Jul 2022 13:26:33 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47386 Mon 16 Jan 2023 15:24:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41897 2, test for interaction p < 0.0001), and among men (test for interaction p < 0.0001). When the underreporting of Indigenous status on the death certificate was taken into account the relative rate increased to 2.17, 95% CI (2.07, 2.29). Indigenous Australians were also more likely to have their dementia coded as 'unspecified' on their death certificate (Odds Ratio 1.92, 95% CI (1.66, 2.21), p<0.0001), compared to the non-Indigenous group. Conclusion: This epidemiological analysis based on population level mortality data demonstrates the higher dementia-related mortality rate for Indigenous Australians especially at younger ages.]]> Mon 15 Aug 2022 12:23:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46183 Mon 14 Nov 2022 10:13:02 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50949 Mon 14 Aug 2023 14:35:52 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43626 Mon 10 Jul 2023 13:54:37 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55061 Mon 08 Apr 2024 12:31:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50759 Mon 07 Aug 2023 14:29:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54635 Mon 05 Aug 2024 09:49:42 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53536 Mon 04 Dec 2023 15:44:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50078 Fri 30 Jun 2023 15:18:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50568 Fri 28 Jul 2023 11:34:42 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52789 Fri 27 Oct 2023 10:22:21 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39219 HFE p.C282Y variant can cause iron overload and hemochromatosis, mostly in homozygous males. Objective: To estimate p.C282Y associations with brain MRI features plus incident dementia diagnoses during follow-up in a large community cohort. Methods: UK Biobank participants with follow-up hospitalization records (mean 10.5 years). MRI in 206 p.C282Y homozygotes versus 23,349 without variants, including T2* measures (lower values indicating more iron). Results: European ancestry participants included 2,890 p.C282Y homozygotes. Male p.C282Y homozygotes had lower T2* measures in areas including the putamen, thalamus, and hippocampus, compared to no HFE mutations. Incident dementia was more common in p.C282Y homozygous men (Hazard Ratio HR = 1.83; 95% CI 1.23 to 2.72, p = 0.003), as was delirium. There were no associations in homozygote women or in heterozygotes. Conclusion: Studies are needed of whether early iron reduction prevents or slows related brain pathologies in male HFE p.C282Y homozygotes.]]> Fri 27 May 2022 11:37:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55388 Fri 24 May 2024 10:34:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48100 Fri 24 Feb 2023 15:31:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38688 n = 70). Data were collected via an online survey from November 2017 to January 2018. Most respondents (97%) agreed with the importance of including people at all stages of dementia in research, yet around three-quarters of respondents perceived ethical and legal rules and processes as unduly restrictive or time-consuming. Researchers reported variable practices in assessing prospective participants' capacity to consent to their studies. Various tools are used for this purpose, ranging from tools designed for research (eg, MacArthur Competence Assessment Tool for Clinical Research) to more general cognitive function screens (eg, Mini Mental State Exam). Few respondents (14%) routinely exclude people from studies who are unable to give their own consent, but instead seek permission from proxy decision-makers, such as legally appointed guardians or family carers. Respondents reported positive and negative outcomes of ethics review processes. Positive outcomes included strengthening the protections for participants with cognitive impairment while negative outcomes included delays and inconsistent decisions from different ethics committees. The findings suggest a need for improved strategies in the research context to assess and enhance the decision-making capacity of people with dementia to support appropriate opportunities for inclusion. Education for ethics committees, proxy decision-makers and other gatekeepers is also needed to reduce barriers to participation in research.]]> Fri 22 Apr 2022 15:34:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53221 Fri 17 Nov 2023 11:49:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43404 Fri 16 Sep 2022 10:12:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49953 Fri 16 Jun 2023 13:49:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40610 n = 1768), at year one (n = 1373) and a restricted cohort (with possible or definite cognitive impairment) at year two (n = 370) had medication regimens documented by a research nurse during a home visit. Anticholinergic medicines were categorized as levels 1-3 (low-high potency) and summed for each participant as a measure of their ACL. RESULTS: Most participants had no change in ACL over time, but there was some turnover in the anticholinergic medications used. The mean change in ACL was 0.012 ± 0.99 from baseline to 12 months and −0.04 ± 1.3 from baseline to 24 months. Cardiovascular drugs were the most commonly used level 1 anticholinergics, followed by antidepressants and opioids. Antidepressants and urologicals were the most commonly used level 3 anticholinergics. The rate of anticholinergic deprescribing was equivalent to the rate of anticholinergic initiation, and commonly involved the level 1 drugs warfarin, furosemide and temazepam, and the level 3 drugs amitriptyline and oxybutynin. People with dementia had a higher ACL at baseline and year one compared with other participants. CONCLUSION: ACL of community-dwelling older people was very stable over time. This may represent lost opportunities for deprescribing as well as potentially inappropriate prescribing, particularly in those with cognitive impairment.]]> Fri 15 Jul 2022 11:49:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44466 Fri 14 Oct 2022 08:43:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48915 Fri 14 Apr 2023 16:30:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48892 Fri 14 Apr 2023 15:30:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47296 Fri 13 Jan 2023 10:45:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47279 Fri 13 Jan 2023 10:24:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41772 Fri 12 Aug 2022 11:56:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38435 80%) thought ARDs would promote autonomy in decision-making and enable opportunities for people with cognitive impairment to be included in research. Respondents indicated concern about directives not being available when needed (71%) and that ethics committees would not accept ARDs (60%). Few respondents had used ARDs, but a majority (from 57-80%) would be willing to offer ARDs for a range of research activities, such as observing behaviour and taking measures, blood samples or scans. Nearly all respondents (92%) agreed that current dissent should override prior wishes stated in an ARD. The survey findings are contextualised with attention to ethics guidelines, laws and practices to support advance research planning.]]> Fri 10 Sep 2021 15:53:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44932 Fri 10 Mar 2023 17:49:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37832 Fri 09 Aug 2024 10:06:54 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51516 Fri 08 Sep 2023 12:05:45 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51370 Fri 01 Sep 2023 13:43:45 AEST ]]>